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PubMed · 6093798

Rapid polyphosphoinositide decrease is an early event in the steroidogenic response of bovine adrenocortical fasciculata cells to angiotensin II.

A J Hadjian·M Culty·E M Chambaz
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Abstract

Addition of angiotensin II (0.3 microM) to bovine adrenal fasciculata cell suspensions prelabeled with [32P] induced a rapid (15 seconds) and marked decrease of the radioactivity from phosphatidylinositol 4,5-biphosphate (62%) and phosphatidylinositol 4-monophosphate (35%). This effect was concentration-dependent and specifically inhibited in the presence of (Sar1-Ala8)-angiotensin II; it was also completely prevented in the absence of extracellular calcium. The present data appear to illustrate the earliest biological response detectable in bovine fasciculata cells under angiotensin II challenge.

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Adrenal CortexAngiotensin IIAnimalsCattleIn Vitro TechniquesKineticsPhosphatidylinositol PhosphatesPhosphatidylinositolsPhosphorus RadioisotopesJournal ArticleResearch Support, Non-U.S. Gov't

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A J Hadjian, M Culty, E M Chambaz. 1984-10-30. Rapid polyphosphoinositide decrease is an early event in the steroidogenic response of bovine adrenocortical fasciculata cells to angiotensin II.. https://doi.org/10.1016/0006-291x(84)91566-3

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