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PubMed · 6095089

Polyoma virus DNA replication requires an enhancer.

J de Villiers·W Schaffner·C Tyndall·S Lupton·R Kamen
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Abstract

Sequences which activate polyoma virus DNA replication are located within a region that also includes the transcriptional enhancer. We demonstrate a cis involvement of enhancers in DNA replication by showing that this region can be replaced by other enhancers, in a position- and orientation-independent manner, and that an immunoglobulin gene enhancer confers tissue-specific replicatory ability.

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DNA ReplicationEnhancer Elements, GeneticGene Expression RegulationGenes, RegulatorImmunoglobulinsPolyomavirusSimian virus 40Transcription, GeneticVirus ReplicationJournal ArticleResearch Support, Non-U.S. Gov't

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J de Villiers, W Schaffner, C Tyndall, S Lupton, R Kamen. Polyoma virus DNA replication requires an enhancer.. https://doi.org/10.1038/312242a0

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