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PubMed · 6095112

Recombinant antibodies possessing novel effector functions.

M S Neuberger·G T Williams·R O Fox
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Abstract

The introduction into lymphocytes of immunoglobulin-gene DNA that has been manipulated in vitro allows the production of novel antibodies. In this way, cell lines have been established that secrete hapten-specific antibodies in which the Fc portion has been replaced either with an active enzyme moiety or with polypeptide displaying c-myc antigenic determinants.

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AnimalsAntibodies, MonoclonalAntigen-Antibody ComplexCell LineChimeraCloning, MolecularDNA Restriction EnzymesDisulfidesGenesHaptensHybridomasImmunoglobulin Fab FragmentsLymphocytesMiceMicrococcal NucleaseOncogenesPlasmacytomaPlasmidsStaphylococcus aureusTransfectionJournal Article

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M S Neuberger, G T Williams, R O Fox. Recombinant antibodies possessing novel effector functions.. https://doi.org/10.1038/312604a0

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