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Cefmenoxime: in vitro activity.

J M Stamm
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Abstract

The in vitro activity of cefmenoxime (SCE-1365 or A-50912), a new semisynthetic cephalosporin antibiotic, was determined for a broad spectrum of 1,234 organisms isolated as part of a multiclinic study. The minimum inhibitory concentration (MIC) of cefmenoxime required to inhibit at least 90 percent of strains tested (MIC90) ranged from 0.12 to 8 micrograms/ml for Enterobacteriaceae. MIC90S were 0.015 and 0.06 microgram/ml for Streptococcus pneumoniae and S. pyogenes, respectively, and 4 micrograms/ml for Staphylococcus aureus. Group D streptococci were less susceptible. The MIC90 of cefmenoxime for Neisseria gonorrhoeae and Hemophilus influenzae was 0.06 microgram/ml. Cefmenoxime was less active against Pseudomonas aeruginosa, Acinetobacter species, and Bacteroides fragilis (MIC50 = 16 micrograms/ml).

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BacteriaCefmenoximeCefotaximeEnterobacteriaceaeMicrobial Sensitivity TestsJournal ArticleResearch Support, Non-U.S. Gov't

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J M Stamm. 1984-12-21. Cefmenoxime: in vitro activity.. https://doi.org/10.1016/s0002-9343(84)80063-7

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