A decrease in guanylate cyclase activity in some tissues of C3H/HeJ mice with retinal dystrophy.

R M Di Giorgio; S Serra; S Macaione; A Caponetti; G Nisticò

PubMed · 6108940

A decrease in guanylate cyclase activity in some tissues of C3H/HeJ mice with retinal dystrophy.

R M Di Giorgio·S Serra·S Macaione·A Caponetti·G Nisticò

Abstract

Guanylate cyclase activity was assayed in homogenates, in particulate and soluble fractions from retina, cerebellum, cerebral cortex and adrenal gland of adult C3H/HeJ mice with a dystrophic retinopathy. In comparison to control mice (DBA/1J), in C3H/HeJ strain a significant decrease in guanylate cyclase activity occurred in homogenates from retina, cerebellum and adrenal gland. In particular a significant decrease was found in particulate fraction of retina, in the soluble fraction of cerebral cortex and cerebellum and in both fractions of the adrenal gland. In contrast to the retina and cerebellum where guanylate cyclase activity in homogenates was found significantly decreased both in the male and female, in the cerebral cortex guanylate cyclase decreased in both sexes although in female this was more marked.

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Adrenal Glands Animals Cerebellum Female Guanylate Cyclase Male Mice Mice, Inbred C3H Mice, Inbred DBA Retina Retinal Degeneration Sex Characteristics Journal Article Research Support, Non-U.S. Gov't

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R M Di Giorgio, S Serra, S Macaione, A Caponetti, G Nisticò. A decrease in guanylate cyclase activity in some tissues of C3H/HeJ mice with retinal dystrophy.. https://pubmed.ncbi.nlm.nih.gov/6108940/

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