Interaction between antidepressants and alpha-adrenergic receptor blocking agents.

I Zebrowska-Lupina; C Kozyrska; M Stelmasiak

PubMed · 6115370

Interaction between antidepressants and alpha-adrenergic receptor blocking agents.

I Zebrowska-Lupina·C Kozyrska·M Stelmasiak

Abstract

Yohimbine and phentolamine administered in doses regarded as blocking presynaptic alpha-adrenoreceptors counteracted locomotor sedation elicited in rats by antidepressant drugs (imipramine, nortriptyline and amitriptyline). The reduction of noradrenaline (NA) utilization in the brain evoked by a single dose of antidepressants and the increase of NA utilization induced by chronic treatment with imipramine or nortriptyline were prevented by yohimbine. The results indicate the role of presynaptic alpha-adrenoceptors in the influence of tricyclic antidepressants on NA neurons in the brain.

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Adrenergic alpha-Antagonists Animals Antidepressive Agents Brain Drug Interactions Male Motor Activity Norepinephrine Rats Receptors, Adrenergic, alpha Journal Article Research Support, Non-U.S. Gov't

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I Zebrowska-Lupina, C Kozyrska, M Stelmasiak. Interaction between antidepressants and alpha-adrenergic receptor blocking agents.. https://pubmed.ncbi.nlm.nih.gov/6115370/

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