beta-Alanine, a possible neurotransmitter in the visual system?

M Sandberg; I Jacobson

doi:10.1111/j.1471-4159.1981.tb04691.x

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beta-Alanine, a possible neurotransmitter in the visual system?

M Sandberg·I Jacobson

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Abstract

The chemically evoked efflux of endogenous amino acids from perfused rabbit superior colliculus (SC) slices was studied. Amino acids in the perfusates were determined fluorimetrically with a precolumn derivatisation method and subsequent separation on an HPLC column. Potassium-induced depolarisation caused a calcium-dependent release of beta-alanine, GABA, glutamate, and aspartate. Veratridine-evoked efflux was essentially similar in selectivity and could be blocked by tetrodotoxin (TTX). The results are indicative of a neurotransmitter role of beta-alanine, GABA, glutamate, and aspartate in the SC of the rabbit.

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Alanine Amino Acids Animals Chromatography, High Pressure Liquid In Vitro Techniques Neurotransmitter Agents Rabbits Superior Colliculi Taurine Veratridine beta-Alanine Journal Article Research Support, Non-U.S. Gov't

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M Sandberg, I Jacobson. 1981. beta-Alanine, a possible neurotransmitter in the visual system?. https://doi.org/10.1111/j.1471-4159.1981.tb04691.x

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