The relationship between molecular connectivity and partition coefficients.

J C Boyd; J S Millership; A D Woolfson

doi:10.1111/j.2042-7158.1982.tb04730.x

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The relationship between molecular connectivity and partition coefficients.

J C Boyd·J S Millership·A D Woolfson

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Abstract

Kier & Hall (1976) demonstrated that a relationship existed between molecular connectivity and Log P (the Log of the octanol/water partition coefficient) for several classes of compounds and also for the combined classes. This work utilized a number of Log P values calculated using Pi values. We have reinvestigated this relationship using experimentally determined Log P values. The results confirm Kier & Hall's findings although different connectivity indices are brought into the equations.

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J C Boyd, J S Millership, A D Woolfson. 1982. The relationship between molecular connectivity and partition coefficients.. https://doi.org/10.1111/j.2042-7158.1982.tb04730.x

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