Neuroendocrine pacemaker for growth, development and ageing.

P S Timiras; V J Choy; D B Hudson

doi:10.1093/ageing/11.2.73

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Neuroendocrine pacemaker for growth, development and ageing.

P S Timiras·V J Choy·D B Hudson

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Abstract

The hypothesis is formulated that ageing is mediated through alteration in a pacemaker system located in the hypothalamus and dependent on serotonin-thyroid hormone interactions. Data in support of this hypothesis include: imbalance in central nervous system (CNS) neurotransmitters with ageing, with serotonin dominance; impairment of hypothalamic neurosecretion; increased heterogeneity of thyrotropin forms secreted from the aged pituitary; and drug and dietary manipulation of CNS serotonin with consequent effects on endocrine function and homeostasis.

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Aging Animals Growth Humans Hypothalamus Neurosecretion Neurotransmitter Agents Norepinephrine Pituitary Gland Polymorphism, Genetic Rats Serotonin Thyroid Gland Thyrotropin Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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P S Timiras, V J Choy, D B Hudson. 1982. Neuroendocrine pacemaker for growth, development and ageing.. https://doi.org/10.1093/ageing%2F11.2.73

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