PubMed · 612745
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N Kageyama, J Yoshida. 1977. [Empty sella syndrome].. https://pubmed.ncbi.nlm.nih.gov/612745/
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The empty sella syndrome has become a rather frequent finding in magnetic resonance imaging (MRI) scanning. The usual presentation of empty sella syndrome involves an incidental finding on a computed tomography scan or an MRI scan. It is unusual to find empty sella syndrome associated with hypopituitarism. The authors describe such an unusual finding in a 54-year-old nulliparous woman.
The use of computed tomography (CT) in 28 patients with surgically proved prolactinomas is described. The authors' experience suggests that in evaluating patients with galactorrhea-amenorrhea syndrome, CT in combination with pluridirectional tomography usually provides sufficient information to make further invasive studies unnecessary. In selected cases with low-density areas within the sella as seen on CT, pneumoencephalography is still advisable to distinguish between the empty sella and the necrotic tumor. Angiography is still necessary to exclude vascular causes for suprasellar and parasellar masses such as aneurysms and meningiomas.
A primary "empty" sella turcica was found incidentally at autopsy, and the anterior lobe of the pituitary gland was studied with the immunoperoxidase technique. All five adenohypophysial cell types, ie, somatotrophs, lactotrophs, corticotrophs, thyrotrophs, and gonadotrophs (containing follicle-stimulating hormone [FSH] and luteinizing hormone [LH], were present in adequate numbers and were well granulated, indicating normal hormone storage.