PubMed · 6134908
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J E Compston, J E Ledger. 1983-07-02. Vitamin D.. https://doi.org/10.1016/s0140-6736(83)90027-2
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A physiologically realistic model was used to investigate through simulation the multiple-dose behavior of drugs subject to enterohepatic cycling. The model included separate liver and gallbladder compartments and instantaneous emptying of the gallbladder at regular intervals of length phi. Two half-lives are described, only one of which is predictive of time to steady state and accumulation. This predictive half-life would be obtained if plasma samples were taken at regular intervals equal to phi, and has been termed the effective half-life. Incorporation of gallbladder emptying at irregular intervals into the model did not materially alter our conclusions regarding the existence and predictive nature of the effective half-life.
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The use of labelled bile salt retention is likely to be a major new technique in assessing the function of the terminal ileum. Papers to date have described two techniques to measure both the 100% and the seven-day retention values. These use whole body counters or uncollimated gamma cameras. We have compared the use of simple probe systems with an uncollimated gamma camera for the retention measurements. There was no significant difference in the results obtained with any of these systems. It is concluded that simple probe measurements can provide a precise and highly reproducible assessment of bile salt retention which greatly increases the availability of this test.