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Glucose utilization in the auditory system: cochlear dysfunctions and species differences.

B Canlon·A Takada·J Schacht
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Abstract

Deoxyglucose uptake in peripheral auditory tissues and inferior colliculus of the young CBA or C57BL/6J mouse increases with intensity of an acoustic stimulus from 25 to 85 dBA and decreases from 85 to 115 dBA. In 36-month-old CBA and 9-month-old C57BL with sensorineural hearing loss the metabolic response to stimulation is attenuated 50% or more. Metabolic responses to stimuli are qualitatively and quantitatively different in the gerbil and in the guinea-pig. It is concluded that cochlear dysfunctions are characterized by abnormal evoked metabolism; and that the stimulus-response pattern varies with species.

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Acoustic StimulationAnimalsCochleaDeoxyglucoseGlucoseLabyrinth DiseasesMaleMiceMice, Inbred C57BLMice, Inbred CBAMice, Inbred StrainsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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B Canlon, A Takada, J Schacht. 1984. Glucose utilization in the auditory system: cochlear dysfunctions and species differences.. https://doi.org/10.1016/0300-9629(84)90089-6

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