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Therapy of solid Walker carcinosarcoma 256 with bleomycin after synchronization with hydroxyurea.

M Volm·J Mattern·N Weber·K Wayss
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Abstract

Rats with the solid Walker carcinosarcoma 256 were synchronized with hydroxyurea (6 x 50 mg/kg or 1 x 300 mg/kg body weight) and treated with bleomycin (32 mg/kg body weight) at different time points thereafter. Bleomycin clearly affects Walker carcinosarcoma cells at the G1/S boundary or in S-phase. The improvement in the results of bleomycin therapy after pretreatment with hydroxyurea can mainly be accounted for by the synchronization of the tumour cells.

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AnimalsBleomycinCarcinoma 256, WalkerCell CycleDose-Response Relationship, DrugDrug Therapy, CombinationHydroxyureaMaleNeoplasm TransplantationRatsTime FactorsJournal Article

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M Volm, J Mattern, N Weber, K Wayss. 1980. Therapy of solid Walker carcinosarcoma 256 with bleomycin after synchronization with hydroxyurea.. https://doi.org/10.1007/bf00254028

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