Angiogenesis in vitro.

J Folkman; C Haudenschild

doi:10.1038/288551a0

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PubMed · 6160403

Angiogenesis in vitro.

J Folkman·C Haudenschild

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Abstract

Cloned capillary endothelial cells, cultured in tumour-conditioned medium, form capillary tubes. By light and electron microscopy these tubes resemble capillaries in vivo. This first demonstration of angiogenesis in vitro: (1) shows that all the information necessary to develop an entire capillary network in vitro is expressed by one cell type; (2) suggests a mechanism for lumen formation; and (3) offers a possibility of distinguishing between direct and indirect angiogenesis factors.

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Angiogenesis Inducing Agents Capillaries Cell Aggregation Cells, Cultured Endothelium Microscopy, Electron Neovascularization, Pathologic Vacuoles Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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J Folkman, C Haudenschild. 1980-12-11. Angiogenesis in vitro.. https://doi.org/10.1038/288551a0

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