Nucleic acids-protein interactions: structural studies by x-ray diffraction and model building.

S H Kim

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PubMed · 6161377

Nucleic acids-protein interactions: structural studies by x-ray diffraction and model building.

S H Kim

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Abstract

X-ray diffraction and model-building studies suggest that the alpha-helix and beta-structure of protein may interact with double-helix nucleic acids. In the former case basic side chains of amino acid residues in the alpha-helix can interact with phosphate groups of the double helix, and in the latter case the peptide backbone in a beta-ribbon can hydrogen-bond to the backbone of the double helix of nucleic acids. These structurally compatible interactions between well-known secondary structures of protein and the double helix provide models for understanding specific interaction between nucleic acid and protein during general recognition, or preliminary stages before base sequence-specific recognition.

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DNA Hydrogen Bonding Models, Theoretical Nucleic Acid Conformation Protein Binding Protein Conformation Proteins RNA Structure-Activity Relationship X-Ray Diffraction Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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S H Kim. 1980. Nucleic acids-protein interactions: structural studies by x-ray diffraction and model building.. https://pubmed.ncbi.nlm.nih.gov/6161377/

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