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PubMed · 6164517

Beta 2-microglobulin and other proteins as parameter for tubular function.

M Weise·D Prüfer·G Jaques·M Keller·A W Mondorf
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Abstract

Urinary excretion of the low molecular weight protein beta 2-microglobulin and tubular enzymes--alanine aminopeptidase (AAP), gamma-glutamyl transpeptidase (gamma-GT) and alkaline phosphatase (AP)--are very sensitive parameters for proximal tubular lesions. In patients with preeclampsia the renal excretion of beta 2-microglobulin allows to differentiate between a primary preeclampsia and a preeclampsia superimposed upon chronic pyelonephritis. In the first group the increase is 3- to 4-fold and in the second group up to 300-fold. In patients with kidney transplantation the urinary excretion of beta 2-microglobulin, AAP, gamma-GT and AP are several times higher than in normals. In case of a rejection episode a further increase of these proteins occur in more than 80% several days before clinical symptoms are present. The application of analgetics (paracetamol, acetylsalicylic acid) in healthy individuals in therapeutical dosages on 3 consecutive days does not show any tubular alteration by the measurement of urinary beta 2-microglobulin. Aminoglycosides (tobramycin, UK 18,892) lead to a cumulative increase of the renal excretion of beta 2-microglobulin and AAP while cephalosporins induce an increase of total proteins in the final urine under the same conditions.

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AcetaminophenAmino Acid SequenceAspirinBeta-GlobulinsFemaleGraft RejectionHumansKidney DiseasesKidney TransplantationKidney TubulesPre-EclampsiaPregnancyPregnancy ComplicationsProteinuriaPyelonephritisTransplantation, Homologousbeta 2-MicroglobulinJournal Article

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M Weise, D Prüfer, G Jaques, M Keller, A W Mondorf. 1981. Beta 2-microglobulin and other proteins as parameter for tubular function.. https://doi.org/10.1159/000395233

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