Hybrid (combinatorial) Ia specificities: gene complementations to generate Ia.22.

W P Lafuse; J F McCormick; P S Corser; C S David

doi:10.1007/bf00524609

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Hybrid (combinatorial) Ia specificities: gene complementations to generate Ia.22.

W P Lafuse·J F McCormick·P S Corser·C S David

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Abstract

Ia specificity 22 is expressed on a hybrid I-E molecule formed by the association of a beta chain (Ae) coded for by the I-A subregion and an alpha chain (E alpha) encoded by the I-E subregion. Ia.22 can be generated by the complementation of Ab, Ak, As, Ar, with Ed, Ek, Ep, Er, Ew3, Eu, Ev but Eb, Ef, Eq, and Es. With the exception of H-2p which does not complement with As to generate Ia.22, all Ia. 7-positive (I-E) haplotypes can provide the permissive E alpha allele. It is postulated that Ia.22 is a combinatorial Ia determinant generated by the association of the alpha and beta chains. These determinants are probably involved in the immune recognition of antigens under dual Ir-gene control.

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Animals Chemical Precipitation Cytotoxicity, Immunologic Epitopes Genetic Complementation Test Histocompatibility Antigens Class II Hybridization, Genetic Mice Mice, Inbred A Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred DBA Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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W P Lafuse, J F McCormick, P S Corser, C S David. 1981. Hybrid (combinatorial) Ia specificities: gene complementations to generate Ia.22.. https://doi.org/10.1007/bf00524609

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