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Electrophoretically pure mouse interferon exerts multiple biological effects.

J De Maeyer-Guignard·E De Maeyer·M G Tovey·I Gresser
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Abstract

Electrophoretically pure (EP) mouse interferon (IF), was examined for a number of biological effects of previously ascribed to crude or partially purified interferon preparations. The following effects were observed: inhibition of antibody formation in vitro; inhibition or enhancement of sensitization to sheep erythrocytes in the mouse, depending on time of administration of IF, and dosage of antigen; inhibition of the expression of delayed type hypersensitivity in vivo; enhancement of natural killer cell activity in vitro and in vivo; inhibition of mouse tumor cells multiplication in vitro; inhibition of the growth of a transplantable tumor in mice. EP mouse IF had a very pronounced priming effect but had no blocking activity.

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AnimalsAntibody FormationCarcinoma, Ehrlich TumorCells, CulturedFemaleImmunity, CellularInterferonsMiceMice, Inbred StrainsComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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J De Maeyer-Guignard, E De Maeyer, M G Tovey, I Gresser. 1980. Electrophoretically pure mouse interferon exerts multiple biological effects.. https://doi.org/10.1111/j.1749-6632.1980.tb20634.x

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