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PubMed · 6165414

The factor VIII complex: structure and function.

L W Hoyer
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Abstract

Normal human plasma contains a complex of two proteins that are important in hemostasis and coagulation. The factor VIII procoagulant protein (antihemophilic factor) and the factor VIII-related protein (von Willebrand factor) are under separate genetic control, have distinct biochemical and immunologic properties, and have unique and essential physiologic functions. While the nature of their interaction and the details of the biochemical structures remain to be determined, the information now available permits a preliminary understanding of the molecular defects in hemophilia and von Willebrand's diseases.

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AnimalsAntibody FormationBlood CoagulationBlood Coagulation FactorsCalciumEpitopesFactor VIIIHemophilia AHemostasisHumansLiverMolecular BiologyMolecular WeightRabbitsRistocetinvon Willebrand Diseasesvon Willebrand FactorJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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L W Hoyer. 1981. The factor VIII complex: structure and function.. https://pubmed.ncbi.nlm.nih.gov/6165414/

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