A general interactive model for B cell activation II. Experimental verification.

A J Rosenspire; D M Jacobs

doi:10.1007/bf02782155

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A general interactive model for B cell activation II. Experimental verification.

A J Rosenspire·D M Jacobs

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Abstract

The general interactive model described in the previous paper was subjected to experimental testing. We examined the high affinity anti-TNP plaque-forming cell response of cultures of murine lymphocytes exposed to lipopolysaccharide and trinitrophenylated lipopolysaccharide (TNP--LPS). From our model we predicted the effects of the addition of free LPS on the dose response to TNP--LPS, the effect of the addition of Polymyxin B to cultures stimulated with TNP--LPS, and the effect on the response to TNP--LPS preparations with different haptenation ratios. The results obtained were consistent with the predictions of the general interactive model.

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Animals B-Lymphocytes Cells, Cultured Escherichia coli Female Haptens Lipopolysaccharides Lymphocyte Activation Mice Models, Biological Polymyxin B Spleen Trinitrobenzenes Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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A J Rosenspire, D M Jacobs. 1981. A general interactive model for B cell activation II. Experimental verification.. https://doi.org/10.1007/bf02782155

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