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PubMed · 6172411

Quantitative evidence for cochlear, non-neuronal norepinephrine.

K E Rarey·M D Ross·C B Smith
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Abstract

Endogenous norepinephrine was quantitatively measured in cochlear tissues of pigmented and nonpigmented animals by high-performance liquid chromatography and electrochemical detection. Epinephrine, dopamine and serotonin were not detected. The cochlear norepinephrine content of the pigmented animals was found to be more than double that present in corresponding albinos. Cochlear norepinephrine was only minimally depleted 48 h after surgical removal of the superior cervical ganglion. 12 h after administration of reserpine (5 mg/kg), cochlear norepinephrine was partially depleted. These results indicate that the norepinephrine located in the cochlea is probably not confined entirely to noradrenergic nerve terminals.

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Adrenergic AgentsAnimalsCatsChromatography, High Pressure LiquidCochleaGanglia, SympatheticGuinea PigsMelaninsNorepinephrinePigmentationRatsRats, Inbred StrainsReserpineComparative StudyJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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K E Rarey, M D Ross, C B Smith. 1981. Quantitative evidence for cochlear, non-neuronal norepinephrine.. https://doi.org/10.1016/0378-5955(81)90029-0

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