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PubMed · 6172499

Dextran-sulfate: a mitogen for human T lymphocytes.

R Palacios·I Sugawara·C Fernandez
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Abstract

Dextran-sulfate (DxS) induced proliferation of human peripheral blood T lymphocytes but not of adult or neonatal B lymphocytes. The mitogenic activity on T cells by DxS required the presence of accessory cells because DxS was unable to trigger T cells to DNA synthesis in the absence of accessory cells. In addition, DxS stimulated OKT4+8- T cells to produce interleukin 2, a process that also occurred only in the presence of accessory cells. Cyclosporin-A strongly suppressed T cell proliferation induced by DxS by rendering T cells unresponsive to interleukin 2 and by inhibiting the synthesis of this T cell growth factor by OKT4+ T cells. These results indicate that DxS is a mitogen for human T lymphocytes but not for adult or neonatal B lymphocytes. The mechanism by which DxS triggers T cells is discussed.

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Antibodies, MonoclonalCyclosporinsDextran SulfateDextransHumansInterleukin-2Lymphocyte ActivationMitogensT-LymphocytesJournal ArticleResearch Support, Non-U.S. Gov't

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R Palacios, I Sugawara, C Fernandez. 1982. Dextran-sulfate: a mitogen for human T lymphocytes.. https://pubmed.ncbi.nlm.nih.gov/6172499/

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