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Antigen-specific soluble helper activity for murine major histocompatibility complex-encoded molecules. I. Kinetics of factor production after skin transplantation and genetic mapping of the H-2 region specificity.

J M Plate·C A McDaniel·L Flaherty·J H Stimpfling·R W Melvold·N Q Martin
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Abstract

Antigen-specific soluble helper molecules are produced during major histocompatibility complex-disparate allograft priming. Genetic mapping studies with appropriate recombinant and mutant lines of mice have defined the antigen specificities of the soluble helper molecules described here as being directed against the H-2Dd molecules. The production of antigen-specific helper molecules is a relatively early event after H-2Dd-region allograft priming. A later phase of factor production near the time of graft rejection also contains nonspecific helper factors and IL-2.

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AnimalsChromosome MappingCross ReactionsEpitopesGenetic CodeH-2 AntigensInterleukin-1Killer Cells, NaturalKineticsMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred DBAMice, Mutant StrainsProtein BiosynthesisRecombination, GeneticSkin TransplantationT-LymphocytesTime FactorsJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J M Plate, C A McDaniel, L Flaherty, J H Stimpfling, R W Melvold, N Q Martin. 1982-03-01. Antigen-specific soluble helper activity for murine major histocompatibility complex-encoded molecules. I. Kinetics of factor production after skin transplantation and genetic mapping of the H-2 region specificity.. https://doi.org/10.1084/jem.155.3.681

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