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Physicochemical analysis of the deoxyribonucleic acid product of murine intracisternal A particle RNA-directed DNA polymerase.

S S Yang·N A Wivel
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Abstract

The nascent DNA transcript of intracisternal A particle RNA-directed DNA polymerase appeared to be covalently linked to an RNA primer. Fidelity of transcription is evident since the DNA transcript hybridized specifically back to 35-70 S RNA of intracisternal A particles but not with heterologous RNAs. This DNA transcript has an approximate molecular weight of 145 000, estimating 350 polynucleotides and base ratios with an excess of dGMP.

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Binding SitesCell LineDNA, NeoplasmMacromolecular SubstancesMolecular WeightNucleic Acid HybridizationRNA-Directed DNA PolymeraseTranscription, GeneticJournal Article

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S S Yang, N A Wivel. 1976-10-04. Physicochemical analysis of the deoxyribonucleic acid product of murine intracisternal A particle RNA-directed DNA polymerase.. https://doi.org/10.1016/0005-2787(76)90340-3

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