Oxygen transfer from bleomycin-metal complexes.

N Murugesan; G M Ehrenfeld; S M Hecht

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PubMed · 6178734

Oxygen transfer from bleomycin-metal complexes.

N Murugesan·G M Ehrenfeld·S M Hecht

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Abstract

Both Fe(III) and Cu(II) complexes of bleomycin (BLM), but not N-acetyl BLM . Fe(III), mediated the transfer of oxygen from iodosobenzene to organic substrates. In analogy with results obtained using certain cytochrome P-450 analogs, cis-stilbene was converted cleanly to the respective oxide, while no more than traces of trans-stilbene oxide were formed from trans-stilbene under identical conditions. The possible relevance of these observations to the degradation of DNA by bleomycin was also studied. In both the presence and absence of O2, BLM . Cu(II) . C6H5IO effected DNA degradation, as judged by the release of [3H]thymine from radiolabeled Escherichia coli DNA. These findings provide a valuable new assay system for the study of bleomycin analogs and suggest the possibility that bleomycin may function as an "oxygen transferase" in its degradation of DNA in situ.

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Bleomycin Chemical Phenomena Chemistry Copper DNA, Bacterial Escherichia coli Ferrous Compounds Iodobenzoates Iron Oxygen Stilbenes Journal Article Research Support, U.S. Gov't, P.H.S.

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N Murugesan, G M Ehrenfeld, S M Hecht. 1982-08-10. Oxygen transfer from bleomycin-metal complexes.. https://pubmed.ncbi.nlm.nih.gov/6178734/

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