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Multiple human beta interferon genes.

A D Sagar·P B Sehgal·D L Slate·F H Ruddle
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Abstract

Analysis of human beta interferon (IFN) mRNA preparations obtained from poly(I) . poly (C)-induced human diploid fibroblasts (FS-4) and from several similarly induced human-mouse somatic cell hybrids by electrophoresis through agarose-CH3HgOH tube gels led to the detection of at least five translationally active human IFN-beta mRNA species. The results obtained are consistent with the existence of IFN-beta genes on different human chromosomes. Marked cell-dependent variability in the expression of these IFN mRNA species was observed.

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AnimalsChromosome MappingChromosomes, HumanChromosomes, Human, 1-3Chromosomes, Human, 4-5Chromosomes, Human, 6-12 and XGenesHumansHybrid CellsInterferonsMiceProtein BiosynthesisRNA, MessengerJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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A D Sagar, P B Sehgal, D L Slate, F H Ruddle. 1982-09-01. Multiple human beta interferon genes.. https://doi.org/10.1084/jem.156.3.744

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