Interferons: chemical properties.

K H Fantes

PubMed · 6184810

Interferons: chemical properties.

Abstract

HuIFN-alpha has been found to consist of a family of 8-10 components. Their amino acid (165 and 166 residues) and nucleotide sequences are similar and also reveal some relationship to that of HuIFN-beta and even to those of murine alpha- and beta-interferons. It is thus likely that all mammalian interferons have originated from a common ancestral gene. Human beta- and some alpha-interferons have been obtained by genetic engineering in E.coli. All interferons seem to contain a relatively high proportion of hydrophobic amino acids and some of the components are glycosylated. The N-terminal residue of all HuIFN-alpha members is probably cysteine, that of the major HuIFN-beta peptide methionine and that of MuIFN-alpha and-beta probably alanine and isoleucine. Very little is known about the chemistry of any of the gamma-interferon species.

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Amino Acid Sequence Animals Cloning, Molecular DNA Escherichia coli Genetic Engineering Humans Interferon Type I Interferon-gamma Interferons Mice Species Specificity Structure-Activity Relationship Comparative Study Journal Article

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K H Fantes. Interferons: chemical properties.. https://pubmed.ncbi.nlm.nih.gov/6184810/

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