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PubMed · 6192346

[Do repetitive DNA sequences have a biological function?].

M E John·W Knöchel
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Abstract

By DNA reassociation kinetics it is known that the eucaryotic genome consists of non-repetitive DNA, middle-repetitive DNA and highly repetitive DNA. Whereas the majority of protein-coding genes is located on non-repetitive DNA, repetitive DNA forms a constitutive part of eucaryotic DNA and its amount in most cases equals or even substantially exceeds that of non-repetitive DNA. During the past years a large body of data on repetitive DNA has accumulated and these have prompted speculations ranging from specific roles in the regulation of gene expression to that of a selfish entity with inconsequential functions. The following article summarizes recent findings on structural, transcriptional and evolutionary aspects and, although by no means being proven, some possible biological functions are discussed.

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AnimalsBase SequenceBiological EvolutionDNAGenesGenetic CodePlantsRNARNA Polymerase IIRNA Polymerase IIIRepetitive Sequences, Nucleic AcidTranscription, GeneticJournal ArticleReview

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M E John, W Knöchel. 1983. [Do repetitive DNA sequences have a biological function?].. https://doi.org/10.1007/bf00405441

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