Substance P and somatostatin regulate sympathetic noradrenergic function.

J A Kessler; J E Adler; I B Black

doi:10.1126/science.6192502

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PubMed · 6192502

Substance P and somatostatin regulate sympathetic noradrenergic function.

J A Kessler·J E Adler·I B Black

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Abstract

Peptidergic-noradrenergic interactions were examined in explants of rat sympathetic superior cervical ganglia and in cultures of dissociated cells. The putative peptide transmitters substance P and somatostatin each increased the activity of the catecholamine-synthesizing enzyme tyrosine hydroxylase after 1 week of exposure in culture. Maximal increases occurred at 10(-7) molar for each peptide, and either increasing or decreasing the concentration reduced the effects. Similar increases in tyrosine hydroxylase were produced by a metabolically stable agonist of substance P, while a substance P antagonist prevented the effects of the agonist. The data suggest that the increased tyrosine hydroxylase activity was mediated by peptide interaction with specific substance P receptors and that peptides may modulate sympathetic catecholaminergic function.

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Animals Bacitracin Captopril Cells, Cultured Culture Techniques Dose-Response Relationship, Drug Ganglia, Sympathetic Rats Somatostatin Substance P Tyrosine 3-Monooxygenase Journal Article

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J A Kessler, J E Adler, I B Black. 1983-09-09. Substance P and somatostatin regulate sympathetic noradrenergic function.. https://doi.org/10.1126/science.6192502

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