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PubMed · 6207263

A common antigenic determinant found in two functionally unrelated toxins.

J Gariepy·P O'Hanley·S A Waldman·F Murad·G K Schoolnik
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Abstract

The heat-stable enterotoxin ST Ib produced by enterotoxigenic E. coli strains shares a sequence homology with the sea snail neurotoxin, conotoxin GI. Rabbit antisera were raised against synthetic analogs of these toxins and to a six-residue peptide representing the region common to both toxins. Results from enzyme-linked immunosorbent assays indicate that the homologous region of both toxins represents part of their antigenic site. The lack of cross-reactivity exhibited by the six-residue common domain with serum directed against either toxin suggests that this region probably retains a similar conformation in the intact toxins but not in the isolated fragment.

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Amino Acid SequenceAnimalsAntitoxinsBacterial ToxinsConotoxinsCross ReactionsEnterotoxinsEpitopesEscherichia coli ProteinsFemaleMiceMollusk VenomsMuscle HypotoniaParalysisRabbitsSnailsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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J Gariepy, P O'Hanley, S A Waldman, F Murad, G K Schoolnik. 1984-10-01. A common antigenic determinant found in two functionally unrelated toxins.. https://doi.org/10.1084/jem.160.4.1253

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