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PubMed · 6208042

Involvement of the D-2 dopamine receptor in the neuroleptic-induced decrease in nigral substance P.

A Oblin·B Zivkovic·G Bartholini
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Abstract

Repeated treatment with, but not single administration of drugs which impair dopaminergic transmission produced a consistent reduction in substance P immunoreactivity in the rat substantia nigra. This effect appears to be related to the D-2 dopamine receptor function as the blockade of this receptor subtype by selective antagonists produced effects qualitatively similar to those produced by drugs lacking selectivity for different subclasses of dopamine receptors.

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AnimalsAntipsychotic AgentsDesipramineMaleRatsRats, Inbred StrainsReceptors, DopamineReceptors, Dopamine D2Substance PSubstantia NigraSynaptic TransmissionJournal Article

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A Oblin, B Zivkovic, G Bartholini. 1984-10-01. Involvement of the D-2 dopamine receptor in the neuroleptic-induced decrease in nigral substance P.. https://doi.org/10.1016/0014-2999(84)90664-2

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