PubMed · 6215438
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W Coryell. 1982. Hypomania.. https://doi.org/10.1016/0165-0327(82)90001-5
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A rapid and selective assay of clomipramine and its metabolite desmethylclomipramine in human plasma, based on high-performance liquid chromatography with UV detection has been developed. The compounds were subjected to solid-phase extraction, using Extrelut 1 cartridges. Recoveries ranged between 88-95% for clomipramine, and 75-80% for desmethylclomipramine. This method has been used for therapeutic monitoring of clomipramine and its metabolite in individuals treated with this drug.
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