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PubMed · 6222098

Isocarboxazid. Efficacy and tolerance.

J Davidson·C Turnbull
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Abstract

In a double-blind study, isocarboxazid was found to have greater efficacy than placebo. Patients with weight gain, increased appetite, and increased sleep responded particularly well, with a rapid onset of improvement that was apparent by one week. Their response to placebo was poor. Using a flexible dose, the modal range was 30-60 mg per day. Higher doses were poorly tolerated. At the doses used, side effects were generally mild, the most common being dizziness and myoclonus.

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Depressive DisorderDose-Response Relationship, DrugDouble-Blind MethodDrug ToleranceFemaleHumansIsocarboxazidMaleJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J Davidson, C Turnbull. 1983. Isocarboxazid. Efficacy and tolerance.. https://doi.org/10.1016/0165-0327(83)90012-5

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