T-cell helper circuits.

M McNamara; K Gleason; H Kohler

doi:10.1111/j.1600-065x.1984.tb00488.x

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T-cell helper circuits.

M McNamara·K Gleason·H Kohler

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Abstract

T helper cells specific for trinitrophenylated PC-binding myeloma and hybridoma antibodies are induced by priming with PC antigen, idiotype or anti-idiotypic antibody. These T helper cells are specific for a shared idiotope present on T15 and M167. Priming with the isolated heavy chains of T15 or M167, or the light chain of anti-T15 hybridoma antibody is equally effective in generating T helper cells. Evidently, the idiotope that is recognized by T cells is not dependent upon the conformation of the 7s Ig molecule. Collectively, these and other findings indicate the existence of a TH1-TH2-B cellular circuit which is based on the recognition of idiotopic determinants on T cell receptors. The implications of these findings in terms of network theory are explored.

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Animals Antibodies, Anti-Idiotypic Antibody Specificity Antigens B-Lymphocytes Immunoglobulin Idiotypes Lymphocyte Cooperation Mice Receptors, Immunologic T-Lymphocytes, Helper-Inducer Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.Review

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M McNamara, K Gleason, H Kohler. 1984. T-cell helper circuits.. https://doi.org/10.1111/j.1600-065x.1984.tb00488.x

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