Opiate receptor function may be modulated through an oxidation-reduction mechanism.

G Marzullo; B Hine

doi:10.1126/science.6246583

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PubMed · 6246583

Opiate receptor function may be modulated through an oxidation-reduction mechanism.

G Marzullo·B Hine

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Abstract

Cupric ion, a thiol oxidant, caused naloxone-reversible analgesia when injected intracerebroventricularly in mice; its potency was close to that of morphine. Dithiothreitol, a thiol reductant, reversed the analgesia induced by cupric ion and antagonized analgesia induced by morphine. Oxidized dithiothreitol had no effect. These findings, together with evidence for redox modification of opiate receptor binding in vitro, suggest that a mechanism of oxidation-reduction of thiols may modulate opiate receptor function.

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Animals Brain Copper Dithiothreitol Male Mice Naloxone Oxidation-Reduction Pain Rats Receptors, Opioid Sulfhydryl Compounds Zinc Journal Article Research Support, U.S. Gov't, P.H.S.

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G Marzullo, B Hine. 1980-06-06. Opiate receptor function may be modulated through an oxidation-reduction mechanism.. https://doi.org/10.1126/science.6246583

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