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PubMed · 6247627

Lithium as an immunologic adjuvant.

L Shenkman·W Borkowsky·B Shopsin
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Abstract

Lithium, an adenylate cyclase inhibitor, stimulates a variety of in vitro indices of immune function, including proliferation of lymphocytes in response to mitogens, rosette formation by T-cells and phagocytosis by macrophages. Lithium enhances these immunologic responses at concentrations comparable to those achieved in patients receiving lithium for treatment of manic-depressive disorders. Lithium may prove to have important therapeutic applications as an immune adjuvant, particularly in immune deficiency states associated with excessive C-AMP production.

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Adjuvants, ImmunologicAdultCyclic AMPFemaleHumansImmunologic Deficiency SyndromesLithiumLymphocytesMacrophagesNeutrophilsCase ReportsJournal Article

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L Shenkman, W Borkowsky, B Shopsin. 1980. Lithium as an immunologic adjuvant.. https://doi.org/10.1016/0306-9877(80)90025-0

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