DNA methylation and gene function.

A Razin; A D Riggs

doi:10.1126/science.6254144

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PubMed · 6254144

DNA methylation and gene function.

A Razin·A D Riggs

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Abstract

In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of many cytosine residues to 5-methylcytosine. For several years, control of gene activity by DNA methylation has been recognized as a logically attractive possibility, but experimental support has proved elusive. However, there is now reason to believe, from recent studies, that DNA methylation is a key element in the hierarchy of control mechanisms that govern vertebrate gene function and differentiation.

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Animals Cell Differentiation DNA DNA (Cytosine-5-)-Methyltransferases DNA Restriction Enzymes Deoxycytosine Nucleotides Deoxyribonucleoproteins Gene Expression Regulation Methylation Methyltransferases Nucleosomes Protein Binding Structure-Activity Relationship Substrate Specificity Tissue Distribution Journal Article Research Support, U.S. Gov't, P.H.S.Review

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A Razin, A D Riggs. 1980-11-07. DNA methylation and gene function.. https://doi.org/10.1126/science.6254144

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