Polymorph leucocyte function in uraemia and jaundice.

E N Wardle; R Williams

doi:10.1159/000207230

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Polymorph leucocyte function in uraemia and jaundice.

E N Wardle·R Williams

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Abstract

Biochemical measures of leucocyte function have been examined using cells from patients with jaundice or uraemia in order to elucidate how toxins might affect those cells and vital enzymes such as NADPH oxidase, myeloperoxidase and esterases. Indices of function were depressed in fulminant hepatic failure, in acute uraemia and in some cases of alcoholic cirrhosis. Conversely there seemed to be an adaptive enzyme increase in chronic uraemia and obstructive jaundice. The toxins which affect leucocyte iodination and myeloperoxidase have been defined.

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Blood Glucose Cholestasis Esterases Humans Iodine Jaundice Leucine Liver Liver Cirrhosis, Alcoholic NADH, NADPH Oxidoreductases NADPH Oxidases Necrosis Neutrophils Oxidation-Reduction Peroxidase Toxins, Biological Uremia Comparative Study Journal Article

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E N Wardle, R Williams. 1980. Polymorph leucocyte function in uraemia and jaundice.. https://doi.org/10.1159/000207230

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