Cyclic nucleotide changes in aortic segments derived from hypertensive rabbits.

J F Tomera; C Harakal

doi:10.1016/0014-2999(80)90428-8

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Cyclic nucleotide changes in aortic segments derived from hypertensive rabbits.

J F Tomera·C Harakal

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Abstract

Mean blood pressure increase was produced by: (1) renal constriction plus contralateral nephrectomy, and (2) cadmium acetate ingestion. Blood pressure was measured directly via the middle ear artery. Cyclic nucleotide levels were determined by 125I-radioimmunoassay. Levels of cAMP were reduced in both hypertensive subgroups when compared to controls. The altered cAMP levels suggest a relationship of this nucleotide to the maintenance of increased blood pressure.

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Animals Aorta, Thoracic Blood Pressure Cadmium Cyclic AMP Female Hypertension Muscle, Smooth, Vascular Nephrectomy Rabbits Time Factors Journal Article Research Support, U.S. Gov't, P.H.S.

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J F Tomera, C Harakal. 1980-12-19. Cyclic nucleotide changes in aortic segments derived from hypertensive rabbits.. https://doi.org/10.1016/0014-2999(80)90428-8

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