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PubMed · 6261940

Non-specific cyclic nucleotide binding in leukemic leukocytes.

T H Weber·J Linkola
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Abstract

Extracts of leukemic lymphocytes and leukemic myelomonocytic cells bind significantly more cAMP/mg protein than do normal cells. The binding of cAMP in leukemic cells is non-specific since the binders are unable to effectively discriminate between cAMP and cGMP in contrast to normal cells. When normal lymphocytes are activated in vitro with mitogens, their cAMP-binding capacity is increased, but the binding retains the specificity of normal cells. Thus in malignantly transformed leukocytes, cAMP-binding is characterized by a high degree of non-specificity, compared with the binding in resting or proliferating normal leukocytes.

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Cyclic AMPCyclic GMPHumansLeukemiaLeukocytesProtein BindingJournal ArticleResearch Support, Non-U.S. Gov't

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T H Weber, J Linkola. 1980. Non-specific cyclic nucleotide binding in leukemic leukocytes.. https://doi.org/10.1016/0304-3835(80)90004-x

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