A model for biological oscillations.

T R Chay

doi:10.1073/pnas.78.4.2204

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A model for biological oscillations.

T R Chay

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Abstract

A model and computation for oscillatory phenomena observed in some biological processes that utilize ion gradients across a membrane is presented. The model contains two main features: (i) active H+ transport pathways in the membrane and (ii) key enzymes having a pH-dependent activity profile and either translocating H+ from outside or producing H+ as a product. With this model a very long period of oscillations, as observed in mitochondrial and circadian rhythms, could be quantitatively demonstrated.

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Biological Transport, Active Carrier Proteins Circadian Rhythm Feedback Hydrogen-Ion Concentration Membrane Potentials Membranes Models, Biological Periodicity Protons Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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T R Chay. 1981. A model for biological oscillations.. https://doi.org/10.1073/pnas.78.4.2204

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