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PubMed · 6275653

Disopyramide anticholinergic action.

A J Byrne·T E Healy·V Mahmoodi·T R Poole
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Abstract

The effect of disopyramide on cholinergic transmission has been studied using the frog isolated abdominis rectus preparation and the guinea pig isolated vas deferens hypogastric nerve preparation. Disopyramide (2 X 10(-5) mol litre-1) reduced the response of the abdominis rectus to carbachol (1.36 X 10(-6)--4.8 X 10(-5) mol litre-1). Furthermore, disopyramide (1 X 10(-6)--3 X 10(-4) mol litre-1) produced a concentration-dependent reduction in the response to carbachol (5.46 X 10(-6) mol litre-1). The response to potassium chloride (3.34 X 10(-2) mol litre-1) was unaltered by disopyramide (1 X 10(-6)--3 X 10(-4) mol litre-1). Disopyramide produced a dose-related ganglionic blockade at concentrations greater than 2 X 10(-5) mol litre-1. Complete blockade to ganglionic transmission occurred at 3 X 10(-4) mol litre-1 disopyramide.

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Abdominal MusclesAnimalsCarbacholDisopyramideDose-Response Relationship, DrugGuinea PigsHypogastric PlexusIn Vitro TechniquesMaleMuscle ContractionParasympatholyticsPotassium ChloridePyridinesRana temporariaReceptors, CholinergicSynaptic TransmissionJournal Article

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BibTeXRIS

A J Byrne, T E Healy, V Mahmoodi, T R Poole. 1981. Disopyramide anticholinergic action.. https://doi.org/10.1111/j.1399-6576.1981.tb01650.x

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