Age-related decrease of in vitro isoproterenol-induced cyclic AMP accumulation in rat aorta.

P Schoeffter; J C Stoclet

doi:10.1016/0014-2999(82)90017-6

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Age-related decrease of in vitro isoproterenol-induced cyclic AMP accumulation in rat aorta.

P Schoeffter·J C Stoclet

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Abstract

Isoproterenol-induced accumulation of cyclic AMP was investigated in aorta rings from 7 to 18 weeks old rats. The effect of isoproterenol on cyclic AMP reached a maximum in 1 min. The concentration-effect curves showed a significant decrease of the maximal accumulation of cyclic AMP as a function of age, without any variation in the effective concentration range. These results parallel the previously reported decrease of beta-adrenergic relaxation of rat aorta with age.

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Aging Animals Aorta, Thoracic Arteries Cyclic AMP DNA Isoproterenol Male Muscle Relaxation Rats Rats, Inbred Strains Time Factors Journal Article Research Support, Non-U.S. Gov't

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P Schoeffter, J C Stoclet. 1982-01-22. Age-related decrease of in vitro isoproterenol-induced cyclic AMP accumulation in rat aorta.. https://doi.org/10.1016/0014-2999(82)90017-6

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