Experimental murine hepatitis and inducible suppressor cell function.

H J Hodgson; J R Wands; K J Isselbacher

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PubMed · 6279850

Experimental murine hepatitis and inducible suppressor cell function.

H J Hodgson·J R Wands·K J Isselbacher

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Abstract

We have investigated the changes in inducible suppressor activity in spleen cells of young BALB/c mice infected with A-59 strain of murine hepatitis virus. The peak histological and biochemical damage occurred four days after intraperitoneal inoculation of the virus. Before that, on day 2, there was a transient loss of suppressor activity inducible in splenic cells by in vitro incubation with the mitogen Con A. Sequential changes in the proliferative response of spleen cells to Con A also occurred, but did not account for the loss of inducible suppressor activity. This variation in activity of Con A-stimulated suppressor cells suggests an immunoregulatory role for these cells during experimental viral hepatitis.

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Animals Concanavalin A Hepatitis, Viral, Animal In Vitro Techniques Lymphocyte Activation Male Mice Mice, Inbred BALB C Murine hepatitis virus Spleen T-Lymphocytes, Regulatory Time Factors Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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H J Hodgson, J R Wands, K J Isselbacher. 1982. Experimental murine hepatitis and inducible suppressor cell function.. https://pubmed.ncbi.nlm.nih.gov/6279850/

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