A model for spontaneous mutation in Drosophila caused by transposing elements.

J N Thompson; R C Woodruff

doi:10.1038/hdy.1981.95

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A model for spontaneous mutation in Drosophila caused by transposing elements.

J N Thompson·R C Woodruff

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Abstract

Transposing genetic elements make up a significant proportion of the DNA of at least some eukaryotes. One of the potential side effects of transposition is a high rate of apparently spontaneous mutation. In this paper we consider some of the evolutionary strategies that might be involved in the suppression of transposition, and we outline a model for the control of spontaneous mutation in terms of the regulation of transposition. Specific predictions are based upon the well-characterized genetics of the mutator system associated with hybrid dysgenesis in Drosophila melanogaster, which has many parallels with the expected behaviour of transposing elements.

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Animals Crosses, Genetic DNA DNA Transposable Elements Drosophila melanogaster Female Hybridization, Genetic Male Models, Genetic Mutation Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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J N Thompson, R C Woodruff. 1981. A model for spontaneous mutation in Drosophila caused by transposing elements.. https://doi.org/10.1038/hdy.1981.95

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