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PubMed · 6282837

Maitotoxin, a Ca2+ channel activator candidate.

M Takahashi·Y Ohizumi·T Yasumoto
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Abstract

Effects of maitotoxin, the most potent marine toxin, were studied using a rat pheochromocytoma cell line, PC12h. A low concentration (10(-8) g/ml) of maitotoxin induced a profound increase in CA2+ influx into PC12h cells and the Ca2+-dependent release of [3H]norepinephrine from them. The effects of maitotoxin were not affected by treatment with tetrodotoxin (10(-6) M) and were observed even in the absence of external Na+. Furthermore, these effects were markedly inhibited or abolished by treatment with verapamil (30-300 microM), Mn2+ (5 mM), or tetracaine (1 mM). These results suggest that maitotoxin activates the voltage-dependent calcium channels of PC12h cells.

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Adrenal Gland NeoplasmsAnimalsCalciumCell LineIon ChannelsKineticsManganeseMarine ToxinsNeoplasms, ExperimentalOxocinsPheochromocytomaRatsTetracaineTetrodotoxinVerapamilPolyether ToxinsJournal Article

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M Takahashi, Y Ohizumi, T Yasumoto. 1982-07-10. Maitotoxin, a Ca2+ channel activator candidate.. https://pubmed.ncbi.nlm.nih.gov/6282837/

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