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PubMed · 6285471

Cellular transforming genes.

G M Cooper
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Abstract

Cellular genes potentially capable of inducing oncogenic transformation have been identified by homology to the transforming genes of retroviruses and by the biological activity of cellular DNA's in transfection assays. DNA's of various tumors induce transformation with high efficiencies, indicating that oncogenesis can involve dominant genetic alterations resulting in activation of cellular transforming genes. The identification and characterization of cellular transforming genes and their possible involvement in naturally occurring cancers, is discussed.

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AnimalsBase SequenceCell Transformation, NeoplasticCells, CulturedChick EmbryoDNADNA Restriction EnzymesDNA, ViralGene Expression RegulationGenesGenes, ViralHumansMiceNeoplasmsOncogene Protein pp60(v-src)RatsRetroviridaeTransfectionViral ProteinsJournal Article

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G M Cooper. 1982-08-27. Cellular transforming genes.. https://doi.org/10.1126/science.6285471

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