Prostaglandins modulate macrophage Ia expression.

D S Snyder; D I Beller; E R Unanue

doi:10.1038/299163a0

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Prostaglandins modulate macrophage Ia expression.

D S Snyder·D I Beller·E R Unanue

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Abstract

Prostaglandins are important modulators of inflammation and of humoral and cellular immune responses. In order to evaluate a possible mechanism for the regulation of immune responses we have studied the effects of prostaglandins on the expression of I-region-associated (Ia) antigens by macrophages. The expression of these glycoproteins is essential for macrophages to function as antigen-presenting cells during the induction of immune responses. The synthesis and membrane expression of Ia, however, is not a constitutive property of the phagocyte but is under regulation and a positive regulation of this process is exhibited by activated T cells. In contrast, a negative regulation is conspicuously found in the neonate where a product from a young replicating macrophage inhibits the expression of Ia by the mature macrophages. We show here that prostaglandins of the E series (PGE) are potent inhibitors of the expression of Ia-antigens on macrophages and that thromboxane B2 (TXB2) antagonizes the effect of PGE.

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Animals Bucladesine Cells, Cultured Dose-Response Relationship, Drug Histocompatibility Antigens Class II Listeriosis Macrophages Mice Prostaglandins Prostaglandins E Thromboxane A2 Time Factors Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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D S Snyder, D I Beller, E R Unanue. 1982-09-09. Prostaglandins modulate macrophage Ia expression.. https://doi.org/10.1038/299163a0

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