Brain cyclic AMP and memory in mice.

C T Randt; M E Judge; K A Bonnet; D Quartermain

doi:10.1016/0091-3057(82)90344-6

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Brain cyclic AMP and memory in mice.

C T Randt·M E Judge·K A Bonnet·D Quartermain

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Abstract

A phosphodiesterase inhibitor 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (Rolipram, 10 mg/kg IP) administered immediately, but not 3 hr post-training, reversed an amnesia for an inhibitory avoidance response induced by the protein synthesis inhibitor anisomycin. Immediate post-training administration of Rolipram also enhanced retention for a weakly learned avoidance response. Unshocked animals did not show increased test latencies thus ruling out conditioned aversion as an explanation for the enhanced avoidance. Mice treated with Rolipram (10 mg/kg after training showed elevated cyclic AMP but not cyclic GMP in frontal cortex, thalamus, and hypothalamus. These results support the suggestion that cyclic AMP may play a role in memory processes.

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Animals Avoidance Learning Brain Cyclic AMP Cyclic GMP Male Memory Mice Pyrrolidinones Rolipram Tissue Distribution Journal Article Research Support, Non-U.S. Gov't

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C T Randt, M E Judge, K A Bonnet, D Quartermain. 1982. Brain cyclic AMP and memory in mice.. https://doi.org/10.1016/0091-3057(82)90344-6

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