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Decrease in the average size of replicons in a Werner syndrome cell line by Simian virus 40 infection.

F Hanaoka·F Takeuchi·T Matsumura·M Goto·T Miyamoto·M Yamada
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Abstract

We have measured the distance between replicon initiation sites as well as the rate of DNA chain elongation in Simian Virus 40 (SV40)-infected and uninfected Werner syndrome (WS) and normal cell lines by DNA fiber-autoradiography. There was no difference in the rate of chain elongation among these cell lines. On the other hand, the replicon center-to-center distance was clearly longer in WS fibroblasts than that in normal fibroblasts. SV40 infection changed the center-to-center distance in WS cells toward that in normal cells.

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AutoradiographyCell LineDNA ReplicationFibroblastsHumansRepliconSimian virus 40Werner SyndromeComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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F Hanaoka, F Takeuchi, T Matsumura, M Goto, T Miyamoto, M Yamada. 1983-04-01. Decrease in the average size of replicons in a Werner syndrome cell line by Simian virus 40 infection.. https://doi.org/10.1016/0014-4827(83)90425-1

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